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Comment
. 2018 Nov 1;23(5):634-635.
doi: 10.1016/j.stem.2018.10.003.

The Harmful Consequences of Increased Fitness in Hematopoietic Stem Cells

Megan E McNerney  1 , Michelle M Le Beau  2
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The Harmful Consequences of Increased Fitness in Hematopoietic Stem Cells

Megan E McNerney et al. Cell Stem Cell. .
Free article

Abstract

Clonal hematopoiesis of indeterminate potential (CHIP) describes clonal selection of a hematopoietic stem cell with a somatic mutation that confers increased fitness, influenced by a selective environment such as aging, inflammation, or therapeutic exposure. In this issue of Cell Stem Cell, Hsu et al. (2018) explore the role of cytotoxic therapy in disease-relevant CHIP.

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