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Review
. 2019 Jan;28(1):33-43.
doi: 10.1016/j.chc.2018.07.003. Epub 2018 Aug 31.

Transcranial Magnetic Stimulation for Adolescent Depression

Paul E Croarkin  1 , Frank P MacMaster  2
Affiliations
Review

Transcranial Magnetic Stimulation for Adolescent Depression

Paul E Croarkin et al. Child Adolesc Psychiatr Clin N Am. 2019 Jan.

Abstract

Adolescent depression is a substantial global public health problem that contributes to academic failure, occupational impairment, deficits in social functioning, substance use disorders, teen pregnancy, and completed suicide. Existing treatment options often have suboptimal results and uncertain safety profiles. Transcranial magnetic stimulation may be a promising, brain-based intervention for adolescents with depression. Existing work has methodological weaknesses, and larger, neurodevelopmentally informed studies are urgently needed. Treatment with transcranial magnetic stimulation may modulate cortical GABAergic and glutamatergic imbalances. Future study will inform dosing approaches for TMS based on GABAergic and glutamatergic biomarkers.

Keywords: Adolescent; Brain stimulation; Depression; GABA; Glutamate; Neuromodulation; TMS; Transcranial magnetic stimulation.

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Figures

Figure 1
Figure 1
Study schema
See this image and copyright information in PMC

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