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Review
. 2018 Dec;47(4):825-837.
doi: 10.1016/j.ecl.2018.07.008.

Skeletal Manifestations of Hypoparathyroidism

Mishaela R Rubin  1
Affiliations
Review

Skeletal Manifestations of Hypoparathyroidism

Mishaela R Rubin. Endocrinol Metab Clin North Am. 2018 Dec.

Abstract

Chronic parathyroid hormone (PTH) deficiency has a marked effect on the skeleton, leading to characteristic decreases in bone remodeling and increases in bone mass. Numerous lines of evidence using biochemical, imaging, and histomorphometric methodologies have demonstrated that the skeleton is altered when PTH is absent and that these abnormalities might be reversed with PTH treatment. More evidence is needed to determine whether fracture risk is altered in hypoparathyroidism.

Keywords: Bone; Histomorphometry; Hypoparathyroidism; Imaging; rhPTH(1-84).

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