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. 2019 Jun;48(6):950-957.
doi: 10.1016/j.semarthrit.2018.10.001. Epub 2018 Oct 9.

Defining multiple joint osteoarthritis, its frequency and impact in a community-based cohort

Terese R Gullo  1 , Yvonne M Golightly  2 , Rebecca J Cleveland  3 , Jordan B Renner  4 , Leigh F Callahan  5 , Joanne M Jordan  5 , Virginia B Kraus  6 , Amanda E Nelson  7
Affiliations

Defining multiple joint osteoarthritis, its frequency and impact in a community-based cohort

Terese R Gullo et al. Semin Arthritis Rheum. 2019 Jun.

Abstract

Background/purpose: To update definitions of multiple joint osteoarthritis (MJOA), and to determine the frequency and impact of MJOA in a community-based cohort.

Methods: Following PRISMA guidelines and with the help of a professional research librarian, we performed a systematic review in Medline using the terms osteoarthritis, generalized, polyarticular, multiple joint, and multi-joint among others, to obtain articles related to MJOA. A total of 42 articles were included for data extraction based on multiple criteria including the requirement for a clearly stated definition of OA assessed at more than one body site. We assessed frequency of these definitions in the Johnston County OA Project (JoCo OA) cohort as well as outcomes related to general health and physical function.

Results: A total of 6 clearly stated definitions for MJOA were identified. These definitions were integrated with a list of 24 definitions from our previous systematic review and distilled down to produce 10 literature-derived, operationalized MJOA definitions. Based on these definitions, high frequencies of radiographic (4-74%) and symptomatic (2-52%) MJOA were found in the JoCo OA. Significant detrimental effects were seen on general health and physical function for most definitions.

Conclusions: We constructed a list of 10 summary MJOA definitions based in the literature that are frequent and associated with important clinical outcomes. These definitions capture some of the variability of MJOA phenotypes and provide a starting point for future analyses of both existing and newly initiated studies.

Keywords: Generalized osteoarthritis; MJOA; Systematic review.

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Figures

Figure 1.
Figure 1.
Diagram of literature search
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References

    1. Murphy L, Helmick CG: The impact of osteoarthritis in the United States: a population-health perspective. Am J Nurs 2012, 112(3 Suppl 1):S13–19. - PubMed
    1. Zhang Y, Jordan JM: Epidemiology of osteoarthritis. Clin Geriatr Med 2010, 26(3):355–369. - PMC - PubMed
    1. Kraus VB, Jordan JM, Doherty M, Wilson AG, Moskowitz R, Hochberg M, Loeser R, Hooper M, Renner JB, Crane MM et al.: The Genetics of Generalized Osteoarthritis (GOGO) study: study design and evaluation of osteoarthritis phenotypes. Osteoarthritis Cartilage 2007, 15(2):120–127. - PubMed
    1. Nelson AE, Renner JB, Schwartz TA, Kraus VB, Helmick CG, Jordan JM: Differences in multijoint radiographic osteoarthritis phenotypes among African Americans and Caucasians: The Johnston County Osteoarthritis project. Arthritis Rheum 2011, 63(12):3843–3852. - PMC - PubMed
    1. Nelson AE, Golightly YM, Renner JB, Schwartz TA, Kraus VB, Helmick CG, Jordan JM: Brief report: differences in multijoint symptomatic osteoarthritis phenotypes by race and sex: the Johnston County Osteoarthritis Project. Arthritis Rheum 2013, 65(2):373–377. - PMC - PubMed

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