Evidence-based Treatment for Low-grade Glioma

Abstract

Objectives: To identify the tumors included in the WHO classification of low-grade gliomas, and review the importance of molecular biomarkers and their implication for treatment, prognosis, and outcomes.

Data sources: Published research, clinical guidelines, educational articles in oncology journals, and Web-based resources.

Conclusion: Molecular neuropathology has influenced the reclassification of low-grade gliomas and, as such, has provided patient-specific treatments with improving outcomes.

Implications for nursing practice: Nurses play a key role in patient education and communication with the patient's interdisciplinary care team. Understanding the molecular neuropathology that determine treatment recommendations and in turn recognizing and identifying complications provides improved patient/caregiver satisfaction and outcomes.

Keywords: classification; isocitrate dehydrogenase; low-grade glioma; molecular neuropathology.