Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2019 Feb;17(1):46-57.e5.
doi: 10.1016/j.clgc.2018.10.002. Epub 2018 Oct 11.

Trends in Renal-Cell Carcinoma Incidence and Mortality in the United States in the Last 2 Decades: A SEER-Based Study

Anas M Saad  1 , Mohamed M Gad  2 , Muneer J Al-Husseini  1 , Inas A Ruhban  3 , Mohamad Bassam Sonbol  4 , Thai H Ho  5
Affiliations

Trends in Renal-Cell Carcinoma Incidence and Mortality in the United States in the Last 2 Decades: A SEER-Based Study

Anas M Saad et al. Clin Genitourin Cancer. 2019 Feb.

Abstract

Background: Renal-cell carcinoma (RCC) is one of the common malignancies in the United States. RCC incidence and mortality have been changing for many reasons. We performed a thorough investigation of incidence and mortality trends of RCC in the United States using the cell Surveillance, Epidemiology, and End Results (SEER) database.

Patients and methods: The 13 SEER registries were accessed for RCC cases diagnosed between 1992 and 2015. Incidence and mortality were calculated by demographic and tumor characteristics. We calculated annual percentage changes of these rates. Rates were expressed as 100,000 person-years.

Results: A total of 104,584 RCC cases were reviewed, with 47,561 deaths. The overall incidence was 11.281 per 100,000 person-years. Incidence increased by 2.421% per year (95% confidence interval, 2.096, 2.747; P < .001) but later became stable since 2008. However, the incidence of clear-cell subtype continued to increase (1.449%; 95% confidence interval, 0.216, 2.697; P = .024). RCC overall mortality rates have been declining since 2001. However, mortality associated with distant RCC only started to decrease in 2012, with an annual percentage change of 18.270% (95% confidence interval, -28.775, -6.215; P = .006).

Conclusion: Despite an overall increase in the incidence of RCC, there has been a recent plateau in RCC incidence rates with a significant decrease in mortality.

Keywords: Kidney cancer; Mortality; Renal cell carcinoma; SEER.

PubMed Disclaimer

Conflict of interest statement

Conflicts of Interest/Disclosure Statements:

All authors declare that they have no conflict of interest.

Figures

Figure 1.
Figure 1.
Trends in annual renal cell carcinoma incidence (1992-2015).
Figure 2.
Figure 2.
Trends in annual renal cell carcinoma incidence-based mortality (1992-2015).
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Cheng L, Zhang S, T MacLennan G, Lopez-Beltran A, Montironi R. Molecular and cytogenetic insights into the pathogenesis, classification, differential diagnosis, and prognosis of renal epithelial neoplasms 2009. 10–29 p. - PubMed
    1. Siegel RL, Miller KD, Jemal A. Cancer statistics, 2018. CA: a cancer journal for clinicians. 2018;68(1):7–30. - PubMed
    1. Chow WH, Dong LM, Devesa SS. Epidemiology and risk factors for kidney cancer. Nature reviews Urology. 2010;7(5):245–57. - PMC - PubMed
    1. Kabaria R, Klaassen Z, Terris MK. Renal cell carcinoma: links and risks. International journal of nephrology and renovascular disease. 2016;9:45–52. - PMC - PubMed
    1. Cumberbatch MG, Rota M, Catto JW, La Vecchia C. The Role of Tobacco Smoke in Bladder and Kidney Carcinogenesis: A Comparison of Exposures and Meta-analysis of Incidence and Mortality Risks. European urology. 2016;70(3):458–66. - PubMed

Publication types