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Case Reports
. 2019 Jan:78:103-106.
doi: 10.1016/j.ijid.2018.10.014. Epub 2018 Oct 25.

High-dose benznidazole in a 62-year-old Bolivian kidney transplant recipient with Chagas central nervous system involvement

M Montero  1 , M Mir  2 , E Sulleiro  3 , J L Avalos Esquivel  2 , E García López  4 , D Molina-Morant  5 , I López Montesinos  4 , L Sorlí  4 , G Veliz Espinosa  2 , E Mounteis Oliva  5 , M Crespo  2 , I Monge  6 , J P Horcajada  4 , S Grau  6 , J Pascual  2
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Free article
Case Reports

High-dose benznidazole in a 62-year-old Bolivian kidney transplant recipient with Chagas central nervous system involvement

M Montero et al. Int J Infect Dis. 2019 Jan.
Free article

Abstract

There is little published data on benznidazole dosing, or levels in cerebrospinal fluid. In this report, we describe the clinical course of an immunosuppressed patient with Chagas central nervous system involvement. He was treated successfully with larger benznidazole doses than are recommended, in order to reach therapeutically effective concentrations in the brain.

Keywords: Benznidazole PK/PD; Benznidazole dose; Chagas disease; Chagoma; Kidney transplant recipient.

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