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Comparative Study
. 1987 Aug;30(8):1482-9.
doi: 10.1021/jm00391a034.

Synthesis and antidepressant properties of novel 2-substituted 4,5-dihydro-1H-imidazole derivatives

M P Wentland, D M Bailey, E J Alexander, M J Castaldi, R A Ferrari, D R Haubrich, D A Luttinger, M H Perrone
Comparative Study

Synthesis and antidepressant properties of novel 2-substituted 4,5-dihydro-1H-imidazole derivatives

M P Wentland et al. J Med Chem. 1987 Aug.

Abstract

A unique combination of alpha 2-adrenoreceptor antagonist and serotonin-selective reuptake inhibitory activities has been identified in a series of 2-substituted 4,5-dihydro-1H-imidazole derivatives. This combination of blocking activities has provided one of these derivatives, napamezole hydrochloride (2), with potential as an antidepressant. A discussion of the syntheses of these compounds includes a convenient method for the conversion of nitriles to imidazolines with ethylenediamine and trimethylaluminum.

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