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. 1987;96(3):277-81.
doi: 10.1007/BF01869309.

D2O and the sodium pump in squid nerve membrane

D Landowne

D2O and the sodium pump in squid nerve membrane

D Landowne. J Membr Biol. 1987.

Abstract

In 10 K artificial seawater (ASW), D2O replacement reduced the Na efflux of squid axons by about one third. In 0 K ASW, D2O replacement had little effect. D2O reduced the K+ sensitivity of the efflux but increased the affinity for K+. A 4 degrees decrease in temperature mimicked the effects of D2O. When axons were injected with arginine, to decrease the ATP/ADP ratio, they lost K+ sensitivity in normal ASW, as expected. Their efflux into 0 K ASW became D2O sensitive. The results are discussed in terms of conformational changes in the Na pump molecular complex.

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