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. 1987 Sep;61(9):2917-20.
doi: 10.1128/JVI.61.9.2917-2920.1987.

A mouse model for poliovirus neurovirulence identifies mutations that attenuate the virus for humans

N La Monica, J W Almond, V R Racaniello

A mouse model for poliovirus neurovirulence identifies mutations that attenuate the virus for humans

N La Monica et al. J Virol. 1987 Sep.

Abstract

A mutation in the genome of poliovirus type 3 that is known to reduce neurovirulence in humans similarly reduces neurovirulence in mice when incorporated into a mouse-adapted-human poliovirus recombinant. Viral recombinants with a uracil at nucleotide position 472 in the 5'-noncoding regions of their genomes are unable to replicate in the mouse brain. Viral recombinants with a cytosine at this position are neurovirulent in mice. Neurovirulence of poliovirus in mice may therefore prove to be a useful indicator of the genetic stability of new attenuating mutations created by site-directed mutagenesis.

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