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. 2018 Dec 15:325:61-63.
doi: 10.1016/j.jneuroim.2018.10.006. Epub 2018 Oct 19.

Antinuclear antibodies in Frontotemporal Dementia: the tip's of autoimmunity iceberg?

I Cavazzana  1 , A Alberici  2 , E Bonomi  3 , R Ottaviani  4 , R Kumar  1 , S Archetti  5 , M Manes  3 , M Cosseddu  6 , E Buratti  7 , A Padovani  3 , A Tincani  8 , F Franceschini  8 , B Borroni  3
Affiliations

Antinuclear antibodies in Frontotemporal Dementia: the tip's of autoimmunity iceberg?

I Cavazzana et al. J Neuroimmunol. .

Abstract

Recent studies suggest a role of the autoimmune system dysregulation in Frontotemporal dementia (FTD). In the present study, we performed a broad immunological screening in a large sample of sporadic FTD patients. We reported a significant increase of antinuclear autoantibodies (ANA) positivity in 100 FTD patients as compared to 100 healthy controls (HC) (60% vs. 13%, p < .001). In FTD, ANA-positive and ANA-negative patients did not differ for any clinical feature. These data extend and further confirm autoimmune dysregulation in FTD. However, it still remains to be clarified whether these antibodies have a potential pathogenic role or represent simply an epiphenomenon.

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