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. 2018 Sep-Oct;70(5):642-648.
doi: 10.1016/j.ihj.2017.11.018. Epub 2017 Nov 22.

Real-time three-dimensional echocardiographic left heart parameters in healthy indian adults

Anupam Bhambhani  1 , Nelson John  2 , Amalu Mathew  3
Affiliations

Real-time three-dimensional echocardiographic left heart parameters in healthy indian adults

Anupam Bhambhani et al. Indian Heart J. 2018 Sep-Oct.

Abstract

Objective: Cardiac chamber dimensions are race and anthropometry dependent. We determined the age and gender specific 3-Dimensional echocardiographic (3DE) reference values for dimensions and function of left ventricle (LV) and left atrium (LA) in normal Indian adults.

Methods: This single center prospective study enrolled 133 adult Indians free of heart disease and/or hypertensions, subjecting them to 3DE measurements of left atrial (LA) & left ventricular (LV) volumes, function and left ventricular mass (LVM). The higher limits of normal cut-offs were determined for these parameters and their dependency on age, gender and anthropometry were analyzed.

Results: The body surface area (BSA) corrected higher limit cut-offs were: 59.37ml/m2 for LV end diastolic volume (59.19ml/m2 and 59.61ml/m2 for men and women, respectively; P=NS); 23.48ml/m2 for LV end systolic volume (23.27ml/m2 and 23.11ml/m2 for men and women, P=NS). Mean LVEF was 64.79%±7.26 (62.99%±6.51 and 67.05%±7.58 in men and women, P=NS). Men had higher LVM than women (119.79g±23.95 vs. 103.26g±23.76, P<0.001), this difference disappeared after BSA indexing. The higher limit cut-offs for normal LA volumes were 20.49ml for minimum volume (21.18ml and 19.46ml for men and women, P=NS) and 39.76ml for maximum volume (39.60ml and 40.03ml in men and women, P=NS). The parameters were smaller compared to western populations but the differences attenuated after BSA indexing.

Conclusions: The study reports normal 3DE parameters of size and function of left heart chambers in Indians.

Keywords: Left atrial emptying fraction; Left atrial volume; Left ventricular end diastolic volume; Left ventricular end systolic volume; Three-dimensional echocardiography.

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Figures

Fig. 1
Fig. 1
3D-echocardiographic determination of left ventricle volumes and function. 4-chamber (top left), 2-chamber (top right) and short axis (bottom left) planes showing semi-automatic tracing of endocardial borders and resultant 3D cast of the LV cavity (bottom right).
Fig. 2
Fig. 2
Intra-observer variability in assessment of LV and LA parameters as analyzed by Bland Altman method (left) and Pearson’s correlation method (right).
See this image and copyright information in PMC

References

    1. Juillière Y., Barbier G., Feldmann L. Additional predictive value of both left and right ventricular ejection fractions on long-term survival in idiopathic dilated cardiomyopathy. Eur Heart J. 1997;18:276–280. - PubMed
    1. Knauth A.L., Gauvreau K., Powell A.J. Ventricular size and function assessed by cardiac MRI predict major adverse clinical outcomes late after tetralogy of Fallot repair. Heart. 2008;94:211–216. - PubMed
    1. Fukuda S., Watanabe H., Daimon M. Normal values of real-time 3-dimensional echocardiographic parameters in a healthy Japanese population: the JAMP-3D Study. Circ J. 2012;76(5):1177–1181. - PubMed
    1. Maffessanti F., Muraru D., Esposito R. Age-, body size-, and sex-specific reference values for right ventricular volumes and ejection fraction by three-dimensional echocardiography: a multicenter echocardiographic study in 507 healthy volunteers. Circ Cardiovasc Imaging. 2013;6(September (5)):700–710. - PubMed
    1. Hinderliter A.L., Light K.C., Willis P.W., 4th Racial differences in left ventricular structure in healthy young adults. Am J Cardiol. 1992;69:1196–1199. - PubMed