doi: 10.1016/0145-2126(87)90029-4.
Phenotypic, cytogenetic and molecular characterization of a new B-chronic lymphocytic leukaemia (B-CLL) cell line
- PMID: 3039258
- DOI: 10.1016/0145-2126(87)90029-4
Item in Clipboard
Phenotypic, cytogenetic and molecular characterization of a new B-chronic lymphocytic leukaemia (B-CLL) cell line
Leuk Res.
1987.
Abstract
A lymphoid cell line was established from a patient with B-cell chronic lymphocytic leukaemia (B-CLL) by infecting blood lymphocytes with Epstein-Barr virus (EBV). Immunoglobulin gene rearrangement studies and the presence of a chromosome marker (isochromosome 17q) provided the formal proof that the line has originated from the neoplastic B cells. The morphology and phenotype indicate that the EBV-induced cell line has reached a plasma cell-like stage of differentiation.
Similar articles
-
Establishment of a new Epstein-Barr virus-immortalized cell line from chronic lymphocytic leukemia with trisomy of chromosome 12 that produces monoclonal IgM against a sheep RBC antigen.Blood. 1988 Jan;71(1):9-12. Blood. 1988. PMID: 2825846
-
Establishment of a lymphoid cell line from leukemic cells of a patient with chronic lymphocytic leukemia.Int J Cancer. 1980 Nov 15;26(5):551-6. doi: 10.1002/ijc.2910260505. Int J Cancer. 1980. PMID: 6263808
-
Karyotype analysis of B-lymphocytes transformed by Epstein-Barr virus in 21 patients with B cell chronic lymphocytic leukemia.Hum Genet. 1983;63(4):327-31. doi: 10.1007/BF00274756. Hum Genet. 1983. PMID: 6305826
-
A review of the prognostic role of cytogenetic, phenotypic, morphologic, and immune function characteristics in chronic lymphocytic leukemia.Blood Cells. 1987;12(2):327-38. Blood Cells. 1987. PMID: 3304471 Review.
-
Human B-lymphoid cell lines.Hum Cell. 1992 Mar;5(1):25-41. Hum Cell. 1992. PMID: 1329931 Review.
Cited by
-
The role of cell maturation in the generation of phenotypic heterogeneity in B-cell chronic lymphocytic leukaemia.Immunology. 1989 Nov;68(3):346-52. Immunology. 1989. PMID: 2531721 Free PMC article.
-
Establishment and characterization of a new Epstein-Barr virus transformed cell line from a human B cell lymphoma.Blut. 1990 Mar;60(3):206-12. doi: 10.1007/BF01720278. Blut. 1990. PMID: 2156585
Publication types
MeSH terms
Substances
LinkOut - more resources
Medical