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. 2018 Nov;57(11):849-857.e2.
doi: 10.1016/j.jaac.2018.06.022. Epub 2018 Sep 3.

Diagnosis of Autism Spectrum Disorder After Age 5 in Children Evaluated Longitudinally Since Infancy

Sally Ozonoff  1 , Gregory S Young  2 , Jessica Brian  3 , Tony Charman  4 , Elizabeth Shephard  4 , Abbie Solish  5 , Lonnie Zwaigenbaum  6
Affiliations

Diagnosis of Autism Spectrum Disorder After Age 5 in Children Evaluated Longitudinally Since Infancy

Sally Ozonoff et al. J Am Acad Child Adolesc Psychiatry. 2018 Nov.

Abstract

Objective: The diagnosis of autism spectrum disorder (ASD) has been found to be remarkably stable but few studies have followed children not initially diagnosed with ASD beyond 3 years of age to examine late or delayed diagnoses. The present study used a prospective familial-risk design to identify children who had undergone multiple comprehensive assessments in preschool and were determined to be negative for ASD only to meet criteria for ASD when tested in middle childhood.

Method: Data were pooled across 3 research teams studying later-born siblings of children with ASD. Fourteen children met inclusion criteria for the late-diagnosed group and were compared with a large sample of high- and low-risk siblings from the same sites who had ASD or typical development (TD) outcomes at 3 years of age.

Results: As a group, the late-diagnosed children scored between the TD and ASD groups on most measures administered at 3 years and differed significantly from the ASD group on most measures. However, there was significant heterogeneity among the late-diagnosed cases. Seven showed very little evidence of ASD in preschool, whereas 7 demonstrated subtle, subthreshold symptomatology.

Conclusion: Some children with ASD might present with a subtle phenotype early in life or show a prolonged time course of symptom development. This emphasizes the need for screening and surveillance schedules that extend past 36 months and continued evaluation of any child who presents with atypical early development and/or high-risk status. The findings also shed light on reasons why the mean age of ASD diagnosis remains older than 4 years.

Keywords: autism spectrum disorder; diagnosis; diagnostic stability.

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Figures

Figure 1:
Figure 1:. Means for All Autism Diagnostic Observation Schedule (ADOS) Items at Age 3 by Group.
Note: The gray areas around the ASD, Non-TD, and TD group mean lines represent the 95% CI. ASD = autism spectrum disorder; TD = typically developing.
See this image and copyright information in PMC

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