Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2018 Dec;17(12):865-886.
doi: 10.1038/nrd.2018.174. Epub 2018 Nov 5.

Mitochondria as a therapeutic target for common pathologies

Michael P Murphy  1 , Richard C Hartley  2
Affiliations
Free article
Review

Mitochondria as a therapeutic target for common pathologies

Michael P Murphy et al. Nat Rev Drug Discov. 2018 Dec.
Free article

Abstract

Although the development of mitochondrial therapies has largely focused on diseases caused by mutations in mitochondrial DNA or in nuclear genes encoding mitochondrial proteins, it has been found that mitochondrial dysfunction also contributes to the pathology of many common disorders, including neurodegeneration, metabolic disease, heart failure, ischaemia-reperfusion injury and protozoal infections. Mitochondria therefore represent an important drug target for these highly prevalent diseases. Several strategies aimed at therapeutically restoring mitochondrial function are emerging, and a small number of agents have entered clinical trials. This Review discusses the opportunities and challenges faced for the further development of mitochondrial pharmacology for common pathologies.

PubMed Disclaimer

References

    1. J Nutr Biochem. 2014 Jan;25(1):66-72 - PubMed
    1. BMC Neurosci. 2016 Jun 10;17(1):33 - PubMed
    1. Oxid Med Cell Longev. 2017;2017:7317251 - PubMed
    1. Nature. 2017 Dec 14;552(7684):187-193 - PubMed
    1. Cell Metab. 2009 May;9(5):449-60 - PubMed

Publication types

MeSH terms

Substances