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. 1987 Jul;7(7):2558-67.
doi: 10.1128/mcb.7.7.2558-2567.1987.

Negative regulation contributes to tissue specificity of the immunoglobulin heavy-chain enhancer

J L Imler, C Lemaire, C Wasylyk, B Wasylyk

Negative regulation contributes to tissue specificity of the immunoglobulin heavy-chain enhancer

J L Imler et al. Mol Cell Biol. 1987 Jul.

Abstract

We have identified in and around the immunoglobulin heavy-chain enhancer two apparently distinct negative regulatory elements which repress immunoglobulin H enhancer, simian virus 40 enhancer, and heterologous promoter activity in fibroblasts but not in myeloma cells. We propose that in nonlymphoid cells, negative regulatory elements prevent activation of the immunoglobulin H enhancer by ubiquitous stimulatory trans-acting factors.

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References

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