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Review
. 2018 Aug 30;5(3):209-219.
doi: 10.1093/jhps/hny027. eCollection 2018 Aug.

The use of platelet-rich plasma in the treatment of greater trochanteric pain syndrome: a systematic literature review

Mohammed Ali  1 , Eshan Oderuth  2 , Ismael Atchia  3 , Ajay Malviya  1
Affiliations
Review

The use of platelet-rich plasma in the treatment of greater trochanteric pain syndrome: a systematic literature review

Mohammed Ali et al. J Hip Preserv Surg. .

Abstract

This review aims to determine whether platelet-rich plasma (PRP) has any role in improving clinical outcomes in patients with symptomatic greater trochanteric pain syndrome (GTPS). A search of NICE healthcare database advanced search (HDAS) via Athens (PubMed, MEDLINE, CINAHL, EMBASE and AMED databases) was conducted from their year of inception to April 2018 with the keywords: 'greater trochanteric pain syndrome' or 'GTPS' or 'gluteus medius' or 'trochanteric bursitis' and 'platelet rich plasma' (PRP). A quality assessment was performed using the JADAD score for RCTs and MINORS for non-RCT studies. Five full-text articles were included for analysis consisting of three RCTs and two case series. We also identified four additional studies from published conference abstracts (one RCT and three case series). The mean age in 209 patients was 58.4 years (range 48-76.2 years). The majority of patients were females and the minimum duration of symptoms was three months. Diagnosis was made using ultrasound or MRI. Included studies used a variety of outcome measures. Improvement was observed during the first 3 months after injection. Significant improvement was also noted when patients were followed up till 12 months post treatment. PRP seems a viable alternative injectable option for GTPS refractory to conservative measures. The current literature has revealed that PRP is relatively safe and can be effective. Considering the limitations in these studies, more large-sample and high-quality randomized clinical trials are required in the future to provide further evidence of the efficacy for PRP as a treatment in GTPS.

Systematic review registration: PROSPERO CRD42017080662.

Level of evidence: Level I, systematic review of Level I studies.

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Figures

Fig. 1.
Fig. 1.
JADAD quality evaluation scale.
Fig. 2.
Fig. 2.
Search results.
Fig. 3.
Fig. 3.
Study selection process.
See this image and copyright information in PMC

References

    1. Bird PA, Oakley SP, Shnier R.. Prospective evaluation of magnetic resonance imaging and physical examination findings in patients with greater trochanteric pain syndrome. Arthritis Rheum 2001; 44: 2138–45. - PubMed
    1. Visser LC, Arnoczky SP, Caballero O.. Growth factor-rich plasma increases tendon cell proliferation and matrix synthesis on a synthetic scaffold: an in vitro study. Tissue Eng Part A 2010; 16: 1021–9. - PubMed
    1. Alsousou J, Thompson M, Harrison P. et al. Effect of platelet-rich plasma on healing tissues in acute ruptured Achilles tendon: a human immunohistochemistry study. Lancet 2015; 385: S19. - PubMed
    1. Fearon AM, Scarvell JM, Cook JL. et al. Does ultrasound correlate with surgical or histologic findings in greater trochanteric pain syndrome? A pilot study. Clin Orthopaedics Relat Res 2010; 468: 1838–44. - PMC - PubMed
    1. Segal NA, Felson DT, Torner JC. et al. Greater trochanteric pain syndrome: epidemiology and associated factors. Arch Phy Med Rehabil 2007; 88: 988–92. - PMC - PubMed