Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2018 Sep;7(Suppl 3):S218-S220.
doi: 10.21037/tlcr.2018.08.10.

Identification of a novel therapeutic target in driver-negative non-small cell lung cancer

Motonobu Saito  1   2 , Koji Kono  1 , Takashi Kohno  2
Affiliations
Editorial

Identification of a novel therapeutic target in driver-negative non-small cell lung cancer

Motonobu Saito et al. Transl Lung Cancer Res. 2018 Sep.
No abstract available

PubMed Disclaimer

Conflict of interest statement

Conflicts of Interest: The authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1
PHIP expression and gene mutation profile in lung adenocarcinoma according to driver aberrations with clinicopathological characteristics. PHIP expression was expressed as the FPKM (fragments per kilobase of exon per million fragments mapped) value, as previously described (17). PHIP, pleckstrin homology domain-interacting protein.
See this image and copyright information in PMC

Comment on

  • PHIP as a therapeutic target for driver-negative subtypes of melanoma, breast, and lung cancer.
    de Semir D, Bezrookove V, Nosrati M, Dar AA, Wu C, Shen J, Rieken C, Venkatasubramanian M, Miller JR 3rd, Desprez PY, McAllister S, Soroceanu L, Debs RJ, Salomonis N, Schadendorf D, Cleaver JE, Kashani-Sabet M. de Semir D, et al. Proc Natl Acad Sci U S A. 2018 Jun 19;115(25):E5766-E5775. doi: 10.1073/pnas.1804779115. Epub 2018 Jun 4. Proc Natl Acad Sci U S A. 2018. PMID: 29866840 Free PMC article.

References

    1. Janku F, Stewart DJ, Kurzrock R. Targeted therapy in non-small-cell lung cancer--is it becoming a reality? Nat Rev Clin Oncol 2010;7:401-14. 10.1038/nrclinonc.2010.64 - DOI - PubMed
    1. Cancer Genome Atlas Research N. Comprehensive molecular profiling of lung adenocarcinoma. Nature 2014;511:543-50. 10.1038/nature13385 - DOI - PMC - PubMed
    1. Ettinger DS, Aisner DL, Wood DE, et al. NCCN Guidelines Insights: Non-Small Cell Lung Cancer, Version 5.2018. J Natl Compr Canc Netw 2018;16:807-21. 10.6004/jnccn.2018.0062 - DOI - PubMed
    1. Kohno T, Ichikawa H, Totoki Y, et al. KIF5B-RET fusions in lung adenocarcinoma. Nat Med 2012;18:375-7. 10.1038/nm.2644 - DOI - PMC - PubMed
    1. Lipson D, Capelletti M, Yelensky R, et al. Identification of new ALK and RET gene fusions from colorectal and lung cancer biopsies. Nat Med 2012;18:382-4. 10.1038/nm.2673 - DOI - PMC - PubMed