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. 1987 Jul 24;15(14):5739-47.
doi: 10.1093/nar/15.14.5739.

The human beta-globin gene contains a downstream developmental specific enhancer

G Kollias, J Hurst, E deBoer, F Grosveld
Free PMC article

The human beta-globin gene contains a downstream developmental specific enhancer

G Kollias et al. Nucleic Acids Res. .
Free PMC article

Abstract

The human beta-globin gene is part of a multigene family and is expressed specifically in adult human erythroid tissue (for review, 1). When the human beta-globin is introduced into fertilized mouse eggs, it is first activated in foetal liver and remains expressed in adult erythroid tissues. It therefore mimicks the pattern of expression of its murine counterpart. It has previously been shown in tissue culture and transgenic mice that sequences downstream from the beta-globin promoter are involved in this regulation. We now show that at least part of these sequences are located 0.5-1.2kb downstream from the poly A addition site and constitute a transcriptional enhancer element that is erythroid and developmental specific.

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References

    1. EMBO J. 1983;2(3):453-62 - PubMed
    1. EMBO J. 1985 Jul;4(7):1715-23 - PubMed
    1. Cell. 1978 Dec;15(4):1125-32 - PubMed
    1. J Natl Cancer Inst. 1980 Apr;64(4):725-38 - PubMed
    1. Proc Natl Acad Sci U S A. 1981 Jan;78(1):348-52 - PubMed

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