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Review
. 2018 Nov;73(8):1045-1055.
doi: 10.1037/amp0000253.

Precision behavioral medicine: Implications of genetic and genomic discoveries for behavioral weight loss treatment

Jeanne M McCaffery  1
Affiliations
Review

Precision behavioral medicine: Implications of genetic and genomic discoveries for behavioral weight loss treatment

Jeanne M McCaffery. Am Psychol. 2018 Nov.

Abstract

This article reviews the concept of precision behavioral medicine and the progress toward applying genetics and genomics as tools to optimize weight management intervention. We discuss genetic, epigenetic, and genomic markers, as well as interactions between genetics and the environment as they relate to obesity and behavioral weight loss to date. Recommendations for the conditions under which genetics and genomics could be incorporated to support clinical decision-making in behavioral weight loss are outlined and illustrative scenarios of how this approach could improve clinical outcomes are provided. It is concluded that there is not yet sufficient evidence to leverage genetics or genomics to aid the treatment of obesity but the foundations are being laid. (PsycINFO Database Record (c) 2018 APA, all rights reserved).

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Figures

Figure 1
Figure 1
Overview of gene x environment interaction for body mass index.
Figure 2
Figure 2
Overview of genetic predictors of weight loss and change in cardiometabolic risk with behavioral intervention.
See this image and copyright information in PMC

References

    1. Agha G, Houseman EA, Kelsey KT, Eaton CB, Buka SL, Loucks EB. Adiposity is associated with DNA methylation profile in adipose tissue. International Journal of Epidemiology. 2015;44(4):1277–1287. - PMC - PubMed
    1. Ahmad S, Rukh G, Varga TV, Ali A, Kurbasic A, Shungin D, … Franks PW. Gene x physical activity interactions in obesity: combined analysis of 111,421 individuals of European ancestry. PLoS Genetics. 2013;9(7):e1003607. - PMC - PubMed
    1. Andreasen CH, Stender-Petersen KL, Mogensen MS, Torekov SS, Wegner L, Andersen G, … Hansen T. Low physical activity accentuates the effect of the FTO rs9939609 polymorphism on body fat accumulation. Diabetes. 2008;57(1):95–101. - PubMed
    1. Aronica L, Levine AJ, Brennan K, Mi J, Gardner C, Haile RW, Hitchins MP. A systematic review of studies of DNA methylation in the context of a weight loss intervention. Epigenomics. 2017;9(5):769–787. - PubMed
    1. Bouchard C, Tremblay A, Despres JP, Theriault G, Nadeau A, Lupien PJ, … Fournier G. The response to exercise with constant energy intake in identical twins. Obesity Research. 1994;2(5):400–410. - PubMed

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