Exercise Mode Specificity for Preserving Spine and Hip Bone Mineral Density in Prostate Cancer Patients
- PMID: 30395051
- DOI: 10.1249/MSS.0000000000001831
Exercise Mode Specificity for Preserving Spine and Hip Bone Mineral Density in Prostate Cancer Patients
Abstract
Purpose: Androgen deprivation therapy (ADT) in men with prostate cancer (PCa) is associated with an array of adverse effects, including reduced bone mineral density (BMD) predisposing patients to increased fracture risk. Our purpose was to examine the effects of targeted exercise modes on BMD in men with PCa undergoing ADT.
Methods: Between 2009 and 2012, 154 PCa patients 43-90 yr old on ADT were randomized to exercise targeting the musculoskeletal system (impact loading + resistance training [ImpRes], n = 57) supervised for 12 months, cardiovascular and muscular systems (aerobic + resistance training, n = 50) supervised for 6 months followed by a 6-month home-based program, or delayed aerobic exercise (DelAer, n = 47) received exercise information for 6 months followed by 6 months of supervised aerobic exercise (stationary cycling). End points were lumbar spine, hip and whole-body BMD measured by dual-energy x-ray absorptiometry with secondary end points of lean and fat mass, appendicular skeletal muscle mass, and neuromuscular strength. ANOVA was used to compare the exercise groups with DelAer at 6 and 12 months.
Results: There was a between-group difference in BMD for ImpRes and DelAer at the spine (6 months, P = 0.039; 12 months, P = 0.035) and femoral neck (6 months, P = 0.050), with decline attenuated in ImpRes (~-1.0% vs ~-2.0%). Compared with DelAer, ImpRes increased appendicular skeletal muscle at 6 months (0.3 kg, P = 0.045) and improved muscle strength at 6 and 12 months (P ≤ 0.012) by 9%-34%. A limitation was inclusion of well-functioning patients.
Conclusion: Combined impact loading and resistance exercise attenuates bone loss at the spine and enhances overall musculoskeletal function in PCa patients undergoing ADT.
Similar articles
-
Immediate versus delayed exercise in men initiating androgen deprivation: effects on bone density and soft tissue composition.BJU Int. 2019 Feb;123(2):261-269. doi: 10.1111/bju.14505. Epub 2018 Sep 21. BJU Int. 2019. PMID: 30239116 Free PMC article. Clinical Trial.
-
Efficacy of recreational football on bone health, body composition, and physical functioning in men with prostate cancer undergoing androgen deprivation therapy: 32-week follow-up of the FC prostate randomised controlled trial.Osteoporos Int. 2016 Apr;27(4):1507-1518. doi: 10.1007/s00198-015-3399-0. Epub 2015 Nov 16. Osteoporos Int. 2016. PMID: 26572756 Clinical Trial.
-
Effects of Different Exercise Modalities on Fatigue in Prostate Cancer Patients Undergoing Androgen Deprivation Therapy: A Year-long Randomised Controlled Trial.Eur Urol. 2017 Aug;72(2):293-299. doi: 10.1016/j.eururo.2017.02.019. Epub 2017 Feb 27. Eur Urol. 2017. PMID: 28249801 Clinical Trial.
-
Physical exercise for bone health in men with prostate cancer receiving androgen deprivation therapy: a systematic review.Support Care Cancer. 2021 Apr;29(4):1811-1824. doi: 10.1007/s00520-020-05830-1. Epub 2020 Oct 29. Support Care Cancer. 2021. PMID: 33119791 Free PMC article.
-
Preventing Osteoporosis in Men Taking Androgen Deprivation Therapy for Prostate Cancer: A Systematic Review and Meta-Analysis.Eur Urol Oncol. 2019 Sep;2(5):551-561. doi: 10.1016/j.euo.2018.11.001. Epub 2018 Nov 24. Eur Urol Oncol. 2019. PMID: 31411986
Cited by
-
Updated systematic review of the effects of exercise on understudied health outcomes in cancer survivors.Cancer Med. 2023 Dec;12(24):22278-22292. doi: 10.1002/cam4.6753. Epub 2023 Nov 29. Cancer Med. 2023. PMID: 38018376 Free PMC article.
-
Effect of exercise on bone-related outcomes in patients with cancer affected by bone metastases or bone loss: a systematic review and meta-analysis.Osteoporos Int. 2025 Aug 6. doi: 10.1007/s00198-025-07645-4. Online ahead of print. Osteoporos Int. 2025. PMID: 40764418 Review.
-
Prevalence of suspected poor bone health in people with chronic obstructive pulmonary disease - a cross-sectional exploratory study.Chron Respir Dis. 2022 Jan-Dec;19:14799731221120429. doi: 10.1177/14799731221120429. Chron Respir Dis. 2022. PMID: 36069319 Free PMC article.
-
Using Exercise and Nutrition to Alter Fat and Lean Mass in Men with Prostate Cancer Receiving Androgen Deprivation Therapy: A Narrative Review.Nutrients. 2021 May 14;13(5):1664. doi: 10.3390/nu13051664. Nutrients. 2021. PMID: 34068965 Free PMC article. Review.
-
Does Androgen Deprivation for Prostate Cancer Affect Normal Adaptation to Resistance Exercise?Int J Environ Res Public Health. 2022 Mar 23;19(7):3820. doi: 10.3390/ijerph19073820. Int J Environ Res Public Health. 2022. PMID: 35409505 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical