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. 2018 Dec 21;63(1):e01832-18.
doi: 10.1128/AAC.01832-18. Print 2019 Jan.

In Vitro Activity of Sulopenem, an Oral Penem, against Urinary Isolates of Escherichia coli

James A Karlowsky  1 , Heather J Adam  1 , Melanie R Baxter  1 , Andrew J Denisuik  1 , Philippe R S Lagacé-Wiens  1 , Andrew J Walkty  1 , Sailaja Puttagunta  2 , Michael W Dunne  2 , George G Zhanel  3
Affiliations

In Vitro Activity of Sulopenem, an Oral Penem, against Urinary Isolates of Escherichia coli

James A Karlowsky et al. Antimicrob Agents Chemother. .

Abstract

The in vitro activity of sulopenem was assessed against a collection from 2014 to 2016 of 539 urinary isolates of Escherichia coli from Canadian patients by using CLSI-defined broth microdilution methodology. A concentration of sulopenem 0.03 µg/ml inhibited both 50% (MIC50) and 90% (MIC90) of isolates tested; sulopenem MICs ranged from 0.015 to 0.25 µg/ml. The in vitro activity of sulopenem was unaffected by nonsusceptibility to trimethoprim-sulfamethoxazole and/or ciprofloxacin, multidrug-resistant phenotypes, extended-spectrum β-lactamases, or AmpC β-lactamases.

Keywords: Escherichia coli; penem; sulopenem; urinary.

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