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. 2018 Oct 26;10(10):138-145.
doi: 10.4252/wjsc.v10.i10.138.

Efficacy and safety of autologous stem cell transplantation for decompensated liver cirrhosis: A retrospective cohort study

Ming-Fang Wang  1 , You-Bing Li  1 , Xiao-Juan Gao  2 , Hao-Yang Zhang  3 , Su Lin  1 , Yue-Yong Zhu  4
Affiliations

Efficacy and safety of autologous stem cell transplantation for decompensated liver cirrhosis: A retrospective cohort study

Ming-Fang Wang et al. World J Stem Cells. .

Abstract

Aim: To evaluate the long-term efficacy and safety of autologous stem cell transplantation (SCT) for decompensated liver cirrhosis.

Methods: Consecutive patients with decompensated liver cirrhosis were included and assigned into the SCT group and non-transplantation (non-SCT) group according to whether they received SCT treatment. Patients were followed up for ten years. The long-term survival rate and incidence of hepatocellular carcinoma (HCC) were compared between groups.

Results: A total of 159 patients were enrolled, including 27 cases in the SCT group and 132 cases in the non-SCT group. The baseline characteristics were significantly different between the two groups. Propensity score matching (PSM) was used to match SCT and non-SCT patients. After PSM, 92 subjects were enrolled in the final analysis, including 23 cases in the SCT group and 69 cases in the non-SCT group. The overall mortality was 73.9% and 55.1%, and the median survival period was 48 and 64 mo, respectively. However, no significant difference was found in the long-term survival rate between the two groups (P > 0.05). In addition, the incidence of HCC was higher in the SCT group than in the non-SCT group (47.8% vs 21.7%, P < 0.05). After adjusting for other covariates, SCT (OR = 3.065, 95%CI: 1.378-6.814) and age (OR = 1.061, 95%CI: 1.021-1.102) were independently correlated with the development of HCC in this decompensated liver cirrhosis cohort.

Conclusion: Autologous SCT may fail to improve the long-term efficacy and increase the incidence of HCC for decompensated liver cirrhosis. Close monitoring of HCC is strongly recommended in patients undergoing autologous SCT.

Keywords: Decompensated liver cirrhosis; Hepatocellular carcinoma; Propensity score matching; Stem cell transplantation.

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Conflict of interest statement

Conflict-of-interest statement: All authors declare no potential conflict of interest.

Figures

Figure 1
Figure 1
Flowchart of the study subject enrollment.
Figure 2
Figure 2
Long-term outcomes of the study subjects. A: Survival curve of the study subjects; B: Risk curve for hepatocellular carcinoma in the study subjects. HCC: Hepatocellular carcinoma.
See this image and copyright information in PMC

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