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. 2018 Oct 31:5:7.
doi: 10.1186/s40734-018-0074-6. eCollection 2018.

Characterization of vitamin D supplementation and clinical outcomes in a large cohort of early Parkinson's disease

Nijee S Luthra  1 , Soeun Kim  2 , Yunxi Zhang  2 , Chadwick W Christine  1   3 ; NINDS NET-PD Investigators
Affiliations

Characterization of vitamin D supplementation and clinical outcomes in a large cohort of early Parkinson's disease

Nijee S Luthra et al. J Clin Mov Disord. .

Abstract

Background: Vitamin D (VitD) deficiency is common in Parkinson's disease (PD) and has been raised as a possible PD risk factor. In the past decade, VitD supplementation for potential prevention of age related conditions has become more common. In this study, we sought to characterize VitD supplementation in early PD and determine as an exploratory analysis whether baseline characteristics or disease progression differed according to reported VitD use.

Methods: We analyzed data from the National Institutes of Health Exploratory Trials in Parkinson's Disease (NET-PD) Long-term study (LS-1), a longitudinal study of 1741 participants. Subjects were divided into following supplement groups according to subject exposure (6 months prior to baseline and during the study): no VitD supplement, multivitamin (MVI), VitD ≥400 IU/day, and VitD + multivitamin (VitD+MVI). Clinical status was followed using the Unified Parkinson's Disease Rating Scale, Symbol Digit Modalities Test, total daily levodopa equivalent dose, and Parkinson's Disease Questionnaire.

Results: About 5% of subjects took VitD alone, 7% took VitD+MVI, 34% took MVI alone, while 54% took no supplement. Clinical outcomes at 3 years were similar across all groups.

Conclusion: This study shows VitD supplementation ≥400 IU/day was not common in early PD and that its use was similar to that seen in the US population. At 3 years, there was no difference in disease progression according to vitamin D supplement use.

Keywords: 1,25-dihydroxyvitamin D; Parkinson’s disease.

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Conflict of interest statement

The NET-PD LS-1 trial was registered at www.clinicaltrials.gov (NCT00449865). Study procedures were reviewed and approved by the institutional review board for each site, and was carried out in accordance with the ethical standards and regulations of each site. Prior to enrollment of participants, each provided written informed consent to study participation.Not applicable, as the manuscript does not contain any individual person’s data.The authors declare that they have no competing interests.Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

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