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. 2019 Jan 2;58(1):221-225.
doi: 10.1002/anie.201811460. Epub 2018 Nov 29.

Carbonylative C-C Bond Activation of Electron-Poor Cyclopropanes: Rhodium-Catalyzed (3+1+2) Cycloadditions of Cyclopropylamides

Andrew G Dalling  1 , Takayuki Yamauchi  1 , Niall G McCreanor  1 , Lydia Cox  1 , John F Bower  1
Affiliations

Carbonylative C-C Bond Activation of Electron-Poor Cyclopropanes: Rhodium-Catalyzed (3+1+2) Cycloadditions of Cyclopropylamides

Andrew G Dalling et al. Angew Chem Int Ed Engl. .

Abstract

Rh-catalyzed carbonylative C-C bond activation of cyclopropylamides generates configurationally stable rhodacyclopentanones that engage tethered alkenes in (3+1+2) cycloadditions. These studies provide the first examples of multicomponent cycloadditions that proceed through C-C bond activation of "simple" electron poor cyclopropanes.

Keywords: C−C activation; cycloaddition; cyclopropane; rhodium.

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