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. 2018 Nov:4:1-9.
doi: 10.1200/JGO.18.00147.

Clinical and Pathologic Profiles of Esophageal Cancer in Mozambique: A Study of Consecutive Patients Admitted to Maputo Central Hospital

Jotamo Come  1 , Clara Castro  1 , Atílio Morais  1 , Matchecane Cossa  1 , Prassad Modcoicar  1 , Satish Tulsidâs  1 , Lina Cunha  1 , Vitória Lobo  1 , Alberto Gudo Morais  1 , Sofia Cotton  1 , Nuno Lunet  1 , Carla Carrilho  1 , Lúcio Lara Santos  1
Affiliations

Clinical and Pathologic Profiles of Esophageal Cancer in Mozambique: A Study of Consecutive Patients Admitted to Maputo Central Hospital

Jotamo Come et al. J Glob Oncol. 2018 Nov.

Abstract

Purpose: Eastern Africa was recently described as a high-incidence geographic area for esophageal cancer. Mozambique is included in this region. This study aimed to characterize this malignant disease at Maputo Central Hospital (MCH) to develop a global program for esophageal cancer management in Mozambique.

Methods: MCH records from between 2012 and 2016 were used to assess the clinical, pathologic, and outcome profiles of esophageal tumors. A descriptive analysis of data collected was performed. Overall survival was evaluated using Kaplan-Meier curves.

Results: In the study, 522 consecutive patient cases of esophageal cancer were recorded. The median patient age was 56.1 years (range, 27 to 97 years); 291 (55.7%) patients were women, and 230 (44.1%) were men. Regarding tumor site, 113 patients (21.6%) had a tumor in the lower third, 154 (29.5%) in the middle, and 50 (9.6%) in the upper third of the esophagus; in the remaining 196 (37.5%), tumor site was unknown. Squamous cell carcinoma comprised 94.4% of cases with documented histopathology (74.9% of the sample). Surgical treatment was possible in 32 patients (6.1%). Disease stage was documented only in these 32 surgical patients; 28.1%, 53.1%, and 18.8% had stage I, II, and III disease, respectively. The remaining patient cases seemed to involve clinically advanced tumors. The median follow-up time was of 1.6 months. The median survival time was of 3.5 months for all patients; for patients treated with curative intent, it was of 8.7 months.

Conclusion: Esophageal carcinoma is a common malignant tumor at MCH and is diagnosed in the advanced stages resulting in poor prognosis. Therefore, implementation of an Esophageal Cancer Program in Mozambique is essential.

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Conflict of interest statement

Jotamo Come

No relationship to disclose

Clara Castro

No relationship to disclose

Atílio Morais

No relationship to disclose

Matchecane Cossa

No relationship to disclose

Prassad Modcoicar

No relationship to disclose

Satish Tulsidâs

No relationship to disclose

Lina Cunha

No relationship to disclose

Vitória Lobo

No relationship to disclose

Alberto Gudo Morais

No relationship to disclose

Sofia Cotton

No relationship to disclose

Nuno Lunet

No relationship to disclose

Carla Carrilho

No relationship to disclose

Lúcio Lara Santos

No relationship to disclose

Figures

Fig 1
Fig 1
Geographic distribution of place of birth of patients by provinces in the country.
Fig 2
Fig 2
Overall survival of patients with esophageal cancer since date of diagnosis.
See this image and copyright information in PMC

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