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Review
. 2018 Dec;45(4):679-694.
doi: 10.1016/j.ogc.2018.07.008. Epub 2018 Oct 25.

Sleep, Health, and Metabolism in Midlife Women and Menopause: Food for Thought

Howard M Kravitz  1 , Rasa Kazlauskaite  2 , Hadine Joffe  3
Affiliations
Review

Sleep, Health, and Metabolism in Midlife Women and Menopause: Food for Thought

Howard M Kravitz et al. Obstet Gynecol Clin North Am. 2018 Dec.

Abstract

Sleep and metabolism are essential components of health. Metabolic health depends largely on individual's lifestyle. Disturbances in sleep health, such as changes in sleep patterns that are associated with menopause/reproductive aging and chronologic aging, may have metabolic health consequences. Sleep restriction and age-related changes in sleep and circadian rhythms may influence changes in appetite and reproductive hormones, energy expenditure, and body adiposity. In this article, the authors describe how menopause-related sleep disturbance may affect eating behavior patterns, immunometabolism, immunometabolic dysfunction, and associations between sleep and metabolic outcomes.

Keywords: Immunometabolism; Menopausal transition; Menopause; Metabolic health; Midlife; Sleep health.

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Figures

Figure 1:
Figure 1:
Sleep with other triggers of immunometabolic dysfunction and relation to healthspan, disease, and disability in midlife women. Sleep can affect immunometabolism directly and through interactions with other triggers. Hormonal regulation: reproductive hormones, adipokines, and other hormones. HALE= healthy life expectancy CVD = cardiovascular disease Courtesy of R. Kazlauskaite, MD, MSc, FACE, Chicago, IL.
See this image and copyright information in PMC

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