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. 2018 Dec:6:46-51.
doi: 10.1016/j.pvr.2018.10.001. Epub 2018 Oct 26.

Single type infection of human papillomavirus as a cause for high-grade cervical intraepithelial neoplasia and invasive cancer in Japan

Jinichi Sakamoto  1 , Shoji Kamiura  2 , Kaori Okayama  3 , Mitsuaki Okodo  4 , Takeo Shibata  1 , Yasuhiro Osaka  1 , Satoko Fujita  1 , Emi Takata  1 , Hiroaki Takagi  1 , Masahiro Takakura  1 , Toshiyuki Sasagawa  5
Affiliations

Single type infection of human papillomavirus as a cause for high-grade cervical intraepithelial neoplasia and invasive cancer in Japan

Jinichi Sakamoto et al. Papillomavirus Res. 2018 Dec.

Abstract

To elucidate oncogenic human papilloma virus (HPV) types in Japan, HPV genotyping was performed in 1526 cervical intraepithelial neoplasia (CIN) and 371 invasive cervical cancer (ICC) patients with the novel Genosearch-31+5 HPV test. The HPV-positive rates were 89.3% and 90.8% in CIN and ICC. Regarding single-type infections, 13 internationally recognized high-risk (13HR) types excluding HPV 35, and probably HR HPV 53, 67, 69, and 70 were identified in ICC, suggesting that all these types may be oncogenic. HPV16 and 18 were identified in both SCC and adenocarcinoma (ADC). HPV HPV52, 31 and 58 (alpha-9) were predominantly detected in SCC, whereas HPV 18, 45, 39 and 59 (alpha-7) were in ADC. The prevalence of HPV 18 in SCC significantly decreased with increasing age of patients, whereas the opposite trend was observed in the other HR types. HPV18 is likely to induce SCC rapidly. All ICC cases aged 20-29 were positive for HPV 16 or 18, suggesting that present HPV 16, 18 vaccines may be quite effective to prevent ICC in young women.

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Figures

Fig. 1
Fig. 1
The prevalence of single-type HPV infections among different cervical intraepithelial neoplasia (CIN) grades. The prevalence of HPV types and groups are plotted according to CIN grade. Single-type infections of HPV 16, 18, high-grade high-risk (HG-HR), low-grade high-risk (LG-HR), probable high-risk (Probable HR), and low-risk (LR) groups were analyzed. HG-HR: HPV 31, 33, 35, 45, 52, and 58. LG-HR: HPV 39, 51, 56, 59, and 68. Probable HR: HPV 26, 53, 66, 67, 69, 70, 73, and 82. LR: HPV 6, 11, 42, 44, 54, 55, 61, 62, 71, 84, 89, and 90.
Fig. 2
Fig. 2
The age-dependent prevalence for single-type HPV infections groups in HSILs (CIN2 and CIN3). The prevalence of HPV types and groups are plotted according to patient age. Single-type infections of HPV 16, 18, high-grade high-risk (HG-HR), low-grade high-risk (LG-HR), probable high-risk (Probable HR), and low-risk (LR) groups were analyzed. HG-HR: HPV 31, 33, 35, 45, 52, and 58. LG-HR: HPV 39, 51, 56, 59, and 68. Probable HR: HPV 26, 53, 66, 67, 69, 70, 73, and 82. LR: HPV 6, 11, 42, 44, 54, 55, 61, 62, 71, 84, 89, and 90.
Fig. 3
Fig. 3
The age-dependent prevalence for single-type HPV infections groups in invasive cervical cancer (ICC). The prevalence of HPV types and groups are plotted according to patient age. Single-type infections of HPV 16, 18, high-grade high-risk (HG-HR), low-grade high-risk (LG-HR), and probable high-risk (Probable HR) groups were analyzed. HG-HR: HPV 31, 33, 35, 45, 52, and 58. LG-HR: HPV 39, 51, 56, 59, and 68. Probable HR: HPV 26, 53, 66, 67, 69, 70, 73, and 82.
Fig. 4
Fig. 4
The age-dependent prevalence for single-type HPV infections groups in squamous cell carcinoma (SCC). The prevalence of HPV types and groups are plotted according to patient age. Single-type infections of HPV 16, 18, high-grade high-risk (HG-HR), low-grade high-risk (LG-HR), and probable high-risk (Probable HR) groups were analyzed. HG-HR: HPV 31, 33, 35, 45, 52, and 58. LG-HR: HPV 39, 51, 56, 59, and 68. Probable HR: HPV 26, 53, 66, 67, 69, 70, 73, and 82.
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