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Comment
. 2018 Dec;10(12):e9484.
doi: 10.15252/emmm.201809484.

Biopsy-free screening for glioma

Alexandre Pellan Cheng  1 , Philip Burnham  1 , Iwijn De Vlaminck  1
Affiliations
Comment

Biopsy-free screening for glioma

Alexandre Pellan Cheng et al. EMBO Mol Med. 2018 Dec.

Abstract

Circulating tumor DNA (ctDNA) is a promising diagnostic marker for many cancers and can be noninvasively assayed from blood. For diagnosing glioma, this approach has unfortunately proven to be of limited use since glioma contribute minimal ctDNA to the blood circulation. A more promising avenue may therefore be to hunt for ctDNA in cerebrospinal fluid (CSF). The study by Mouliere et al in this issue of EMBO Molecular Medicine demonstrates that shallow whole‐genome sequencing of CSF‐cfDNA can be used to detect copy number alterations in glioma‐derived ctDNA, providing a low cost strategy to screen for glioma.

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Figures

Figure 1
Figure 1. Study overview and schematic of low‐cost strategy to screen for glioma
cfDNA derived from glioma is much more prevalent in CSF than in plasma. In this issue of EMBO Molecular Medicine, Mouliere et al report a low‐cost strategy to screen for glioma that takes advantage of shallow whole‐genome sequencing of CSF‐cfDNA and careful examination of structural features on both short and long molecular length scales.
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References

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