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. 2018 Oct 18;4(Suppl 1):e000783.
doi: 10.1136/rmdopen-2018-000783. eCollection 2018.

Mixed connective tissue disease: state of the art on clinical practice guidelines

Benjamin Chaigne  1 , Carlo Alberto Scirè  2 , Rosaria Talarico  3 , Tobias Alexander  4 , Zahir Amoura  5 , Tadej Avcin  6 , Lorenzo Beretta  7 , Andrea Doria  8 , Aurelien Guffroy  9 , Vera Guimarães  10 , Éric Hachulla  11 , Thomas Krieg  12 , David Launay  11 , Gemma Lepri  13 , Pia Moinzadeh  12 , Ulf Müller-Ladner  14 , Simona Rednic  15 , Ana Rodrigues  16 , Sander W Tas  17 , Ronald F van Vollenhoven  18 , Ana Vieira  19 , Stefano Bombardieri  20 , João Eurico Fonseca  21 , Ilaria Galetti  22 , Matthias Schneider  23 , Vanessa Smith  24   25 , Maurizio Cutolo  26 , Marta Mosca  3 , Rebecca Fischer-Betz  23
Affiliations

Mixed connective tissue disease: state of the art on clinical practice guidelines

Benjamin Chaigne et al. RMD Open. .

Abstract

Mixed connective tissue disease (MCTD) is a complex overlap disease with features of different autoimmune connective tissue diseases (CTDs) namely systemic sclerosis, poly/dermatomyositis and systemic lupus erythematous in patients with antibodies targeting the U1 small nuclear ribonucleoprotein particle. In this narrative review, we summarise the results of a systematic literature research which was performed as part of the European Reference Network on Rare and Complex Connective Tissue and Musculoskeletal Diseases project, aimed at evaluating existing clinical practice guidelines (CPGs) or recommendations. Since no specific CPGs on MCTD were found, other CPGs developed for other CTDs were taken into consideration in order to discuss what can be applied to MCTD even if designed for other diseases. Three major objectives were proposed for the future development of CPGs: MCTD diagnosis (diagnostic criteria), MCTD initial and follow-up evaluations, MCTD treatment. Early diagnosis, epidemiological data, assessment of burden of disease and QOL aspects are among the unmet needs identified by patients.

Keywords: ERN reconnet; clinical practice guidelines; european reference networks; mixed connective tissue disease; unmet needs.

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Conflict of interest statement

Competing interests: None declared.

Figures

Figure 1
Figure 1
Flow diagram of the systematic literature search on mixed connective tissue disease (MCTD) clinical practice guidelines.
See this image and copyright information in PMC

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