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Review
. 2018 Oct 8:2018:3819714.
doi: 10.1155/2018/3819714. eCollection 2018.

Natural Antispasmodics: Source, Stereochemical Configuration, and Biological Activity

Edith Fabiola Martínez-Pérez  1   2 , Zaida N Juárez  3 , Luis R Hernández  2 , Horacio Bach  1
Affiliations
Review

Natural Antispasmodics: Source, Stereochemical Configuration, and Biological Activity

Edith Fabiola Martínez-Pérez et al. Biomed Res Int. .

Abstract

Natural products with antispasmodic activity have been used in traditional medicine to alleviate different illnesses since the remote past. We searched the literature and compiled the antispasmodic activity of 248 natural compounds isolated from terrestrial plants. In this review, we summarized all the natural products reported with antispasmodic activity until the end of 2017. We also provided chemical information about their extraction as well as the model used to test their activities. Results showed that members of the Lamiaceae and Asteraceae families had the highest number of isolated compounds with antispasmodic activity. Moreover, monoterpenoids, flavonoids, triterpenes, and alkaloids were the chemical groups with the highest number of antispasmodic compounds. Lastly, a structural comparison of natural versus synthetic compounds was discussed.

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Figures

Figure 1
Figure 1
Number of isolated compounds with antispasmodic activity. The total number was obtained from Table 3. “Others” is the sum of the compounds belonging to alcohols, amines, benzofurans, chalcones, coumarins, curcuminoids, isothiocyanates, ketones, phenolic, phenylmethanoids, phenylethanoids, glucinols, and phloroglucinols.
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