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Clinical Trial
. 2018 Oct 4:2018:7162478.
doi: 10.1155/2018/7162478. eCollection 2018.

A Retrospective Study on the Risk of Respiratory Distress Syndrome in Singleton Pregnancies with Preterm Premature Rupture of Membranes between 24+0 and 36+6 Weeks, Using Regression Analysis for Various Factors

Anna Niesłuchowska-Hoxha  1 , Wojciech Cnota  1 , Bartosz Czuba  1 , Aleksandra Ruci  1 , Magdalena Ciaciura-Jarno  1 , Agnieszka Jagielska  1 , Dominik Wójtowicz  1 , Rafał Kierach  1 , Krzysztof Dąbrowski  1 , Marcin Sidorowicz  1 , Wioletta Skrzypulec-Plinta  2 , Agata Wloch  1 , Dariusz Borowski  3 , Piotr Węgrzyn  4
Affiliations
Clinical Trial

A Retrospective Study on the Risk of Respiratory Distress Syndrome in Singleton Pregnancies with Preterm Premature Rupture of Membranes between 24+0 and 36+6 Weeks, Using Regression Analysis for Various Factors

Anna Niesłuchowska-Hoxha et al. Biomed Res Int. .

Abstract

Aim: This study aimed to investigate the cause of respiratory distress syndrome (RDS) in neonates from singleton pregnancies with preterm premature rupture of membranes (pPROM) between 24+0 and 36+6 weeks by using regression analysis for various factors.

Methods: In 175 singleton pregnancies with pPROM, 95 cases of RDS (54,29%) were diagnosed. In all cases the following information was collected: latency period of PROM, gestational age at birth, Umbilical Artery Pulsatility Index (UA PI), Middle Cerebral Artery Pulsatility Index (MCA PI), fetal distress, antenatal steroids use, delivery type, pregnancy hypertension disease, gestational glucose intolerance or diabetes, neonatal laboratory parameters, gender, weight, Apgar score, and other neonatal complications. Logistic regression analysis was used to investigate the effect of variables on RDS.

Results: The results of logistic regression analysis showed that the following variables are closely correlated with RDS: female gender (OR=0.52; 95%CI:0.28-0,97), antenatal steroids use (OR=0,46; 95%CI:0,34-0,64), abnormal UA PI and MCA PI (OR=2.96; 95%CI:1,43-6,12) (OR=2.05; 95%CI:1,07-3,95), fetal distress (OR=2.33; 95%CI:1,16-4,71), maternal HGB (OR=0.69; 95%CI:0,5-0,96), and neonatal RBC, HGB (OR=0.32; 95%CI:0,19-0,55) (OR=0.75; 95%CI:0,65-0,88).

Conclusions: The main RDS risk factors in premature neonates are gender, abnormal fetoplacental circulation, and fetal distress. The laboratory parameters such as lower RBC and HGB count are observed in infants with RDS.

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Figures

Figure 1
Figure 1
Odds ratios and confidence intervals for variables affecting the occurrence of preterm neonatal RDS–univariate logistic regression.
Figure 2
Figure 2
Odds ratios and confidence intervals for variables affecting the occurrence of preterm neonatal RDS-multivariate logistic regression.
See this image and copyright information in PMC

References

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