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. 2017 Aug 4;1(1):21-27.
doi: 10.5414/ALX01401E. eCollection 2017.

Food-induced anaphylaxis and cofactors - data from the anaphylaxis registry

M Worm  1 , K Scherer  2 , A Köhli-Wiesner  3 , F Ruëff  4 , V Mahler  5 , L Lange  6 , R Treudler  7 , E Rietschel  8 , Z Szepfalusi  9 , R Lang  10 , U Rabe  11 , T Reese  12 , N Schwerk  13 , K Beyer  14 , S Hompes  1 , A Bircher  2 , B Przybilla  4 , T Hawranek  10 , G Hansen  13 , F Friedrichs  15 , H Merk  16 , K Tenbrock  17 , S Lehmann  17 , M Gerstlauer  18 , J Kleine-Tebbe  19 , B Niggemann  20 , H Dickel  21 , M Bücheler  22 , T Bieber  23 , J Hanfland  23 , S Schmitt-Grohe  24 , D Vlajnic  24 , V Heckmann  25 , K Nemat  26 , K Schäkel  27 , A Nordwig  28 , A Schuster  29 , S Schweitzer-Krantz  30 , U Hillen  31 , M Kopp  32 , C Szliska  33 , J Klinge  34 , I Neustädter  34 , T Fuchs  35 , R Bruns  36 , C Marsch  37 , B Kreft  37 , E Coors  38 , W Rebien  39 , B Wedi  40 , C Pföhler  41 , M Rett  42 , M Henzgen  43 , P Vöhringer  44 , R Fölster-Holst  45 , N Hunzelmann  46 , G Siebenhaar  46 , S Nestoris  47 , C Schirpke  48 , J Grabbe  49 , G Stichtenoth  50 , J Ring  51 , K Brockow  51 , R Brehler  52 , I Yildiz  53 , S Volkmuth  54 , M Geißler  55 , M Polz  56 , F Riffelmann  57 , S Thies  58 , U Lepp  59 , U Rabe  11 , H Rebmann  60 , T Spindler  61 , L Klimek  62 , O Pfaar  62 , W Brosi  63 , W Aberer  64 , E Varga  65 , N Reider  66 , I Huttegger  67 , T Kinaciyan  68 , K Hoffmann-Sommergruber  68 , P Eng  69   70 , A Helbling  71 , P Eigenmann  72 , R Guggenheim  73 , P Schmid-Grendelmeier  74
Affiliations

Food-induced anaphylaxis and cofactors - data from the anaphylaxis registry

M Worm et al. Allergol Select. .

Abstract

Food allergens are frequent causes of anaphylaxis. In particular in children and adolescents they are the most frequent elicitors of severe allergic reactions, and in adults food allergens rank third behind insect venom and drugs. Since July 2006 severe allergic reactions from Germany, Austria, and Switzerland are collected in the anaphylaxis registry. Currently 78 hospitals and private practises are connected. From July 2006 until February 2009 1,156 severe allergic reactions were registered. Among children and adolescents (n = 187, age range from 3 months to 17 years) food allergens were the most frequent triggers, comprising 58% of cases. In the adult group (n = 968, 18 - 85 years) food allergens were in the third position (16.3%) behind insect venom and drugs. In children legumes (31%) and in particular peanuts were frequently responsible food allergens, followed by tree nuts (25%) with hazelnut being the most frequent elicitor. In adults fruits (13.4%) most often induced severe food-dependent anaphylaxis, but also animal products (12.2%); among these most frequently crustaceans and molluscs. Cofactors were often suspected in food-dependent anaphylaxis, namely in 39% of the adult group and in 14% of the pediatric group. In adults drugs (22%) and physical activity (10%) were reported to be the most frequent cofactors, in children physical activity was suspected in 8.7% and drugs in 2.6%. Concomitant diseases like atopic dermatitis, allergic asthma, or allergic rhinoconjunctivitis were reported in 78% of children and adolescents and in 67% of the adults. In conclusion, food-induced anaphylaxis, its cofactors and concomitant diseases are age-dependent. The data offers to identify risk factors of anaphylaxis.

Keywords: anaphylaxis; cofactors; food allergens; registry.

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Figures

Figure 1.
Figure 1.. Cofactors in children/adolescents (n = 16) and adults (n = 60) when foods are indicated as triggers of allergic reactions.
Figure 2
Figure 2. Figure 2. Frequency of underlying diseases in children/adolescents (n = 115) and adults (n = 156).
See this image and copyright information in PMC

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  • pp. 329-337

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