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Randomized Controlled Trial
. 2019 May;29(5):2457-2464.
doi: 10.1007/s00330-018-5808-1. Epub 2018 Nov 6.

Patients' experience of screening CT colonography with reduced and full bowel preparation in a randomised trial

Lapo Sali  1   2 , Leonardo Ventura  3 , Grazia Grazzini  3 , Alessandra Borgheresi  4 , Silvia Delsanto  5 , Massimo Falchini  6 , Beatrice Mallardi  3 , Paola Mantellini  3 , Stefano Milani  6 , Stefano Pallanti  7 , Marco Zappa  3 , Mario Mascalchi  6
Affiliations
Randomized Controlled Trial

Patients' experience of screening CT colonography with reduced and full bowel preparation in a randomised trial

Lapo Sali et al. Eur Radiol. 2019 May.

Abstract

Objectives: To assess patients' experience of bowel preparation and procedure for screening CT colonography with reduced (r-CTC) and full cathartic preparation (f-CTC) that showed similar detection rate for advanced neoplasia in a randomised trial.

Methods: Six hundred seventy-four subjects undergoing r-CTC and 612 undergoing f-CTC in the SAVE trial were asked to complete two pre-examination questionnaires-(1) Life Orientation Test - Revised (LOT-R) assessing optimism and (2) bowel preparation questionnaire-and a post-examination questionnaire evaluating overall experience of CTC screening test. Items were analysed with chi-square and t test separately and pooled.

Results: LOT-R was completed by 529 (78%) of r-CTC and by 462 (75%) of f-CTC participants and bowel preparation questionnaire by 531 (79%) subjects in the r-CTC group and by 465 (76%) in the f-CTC group. Post-examination questionnaire was completed by 525 (78%) subjects in the r-CTC group and by 453 (74%) in the f-CTC group. LOT-R average score was not different between r-CTC (14.27 ± 3.66) and f-CTC (14.54 ± 3.35) (p = 0.22). In bowel preparation questionnaire, 88% of r-CTC subjects reported no preparation-related symptoms as compared to 70% of f-CTC subjects (p < 0.001). No interference of bowel preparation with daily activities was reported in 80% of subjects in the r-CTC group as compared to 53% of subjects in the f-CTC group (p < 0.001). In post-examination questionnaire, average scores for discomfort of the procedure were not significantly different between r-CTC (3.53 ± 0.04) and f-CTC (3.59 ± 0.04) groups (p = 0.84).

Conclusions: Reduced bowel preparation is better tolerated than full preparation for screening CT colonography.

Key points: • Reduced bowel preparation is better tolerated than full preparation for screening CT colonography. • Procedure-related discomfort of screening CT colonography is not influenced by bowel preparation. • Males tolerate bowel preparation and CT colonography screening procedure better than females.

Keywords: CT colonography; Questionnaire; Virtual colonoscopy.

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