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. 1977 Nov;33(5):721-5.

The influence of antigen presentation on the generation of T-helper cells with different functions

H Waldmann, H Pope

The influence of antigen presentation on the generation of T-helper cells with different functions

H Waldmann et al. Immunology. 1977 Nov.

Abstract

Thymocytes adoptively transferred into syngeneic irradiated recipients can be primed with antigen (KLH) to generate two types of helper function termed 'specific' and 'non-specific'. Low doses of KLH given without adjuvant generate high levels of non-specific compared to 'specific' helper T cells. Large doses of KLH given in adjuvant (FCA) generate high levels of both types of helper T cell. Explantations for this observation are discussed.

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References

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