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. 2018 Nov;58(11):2483-2489.
doi: 10.1111/trf.14871. Epub 2018 Sep 28.

How we evaluate red blood cell compatibility and transfusion support for patients with sickle cell disease undergoing hematopoietic progenitor cell transplantation

Elizabeth S Allen  1   2 , Randin C Nelson  1   3 , Willy A Flegel  1
Affiliations

How we evaluate red blood cell compatibility and transfusion support for patients with sickle cell disease undergoing hematopoietic progenitor cell transplantation

Elizabeth S Allen et al. Transfusion. 2018 Nov.

Abstract

Multiple hematopoietic progenitor cell (HPC) transplantation options for patients with sickle cell disease (SCD) are currently under investigation. Patients with SCD have a high rate of alloimmunization to red blood cell antigens, often complicating transfusion support. Transfusion reactions, including acute and delayed hemolytic reactions, have been observed despite immunosuppressive regimens. Allogeneic donor transplants have been shown to carry a risk of prolonged reticulocytopenia and acute hemolysis with severe anemia in nonmyeloablative regimens. We discuss our experience providing transfusion support to patients with SCD undergoing HPC transplantation, propose an outline for a complete pretransplantation evaluation, and discuss donor/recipient compatibility issues and their implications.

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Conflict of interest statement

CONFLICT OF INTEREST

The authors have disclosed no conflicts of interest.

Figures

Fig. 1.
Fig. 1.
Template for a transfusion medicine consultation in the pretransplantation setting for a patient with SCD.
See this image and copyright information in PMC

References

    1. Arnold SD, Bhatia M, Horan J, et al. Haematopoietic stem cell transplantation for sickle cell disease — current practice and new approaches. Br J Haematol 2016;174:515–25. - PubMed
    1. Walters MC, De Castro LM, Sullivan KM, et al. Indications and results of HLA-identical sibling hematopoietic cell transplantation for sickle cell disease. Biol Blood Marrow Transplant 2016; 22:207–11. - PMC - PubMed
    1. McPherson ME, Anderson AR, Haight AE, et al. Transfusion management of sickle cell patients during bone marrow transplantation with matched sibling donor. Transfusion 2009;49: 1977–86. - PubMed
    1. Klein HG, Anstee DJ. Mollison’s blood transfusion in clinical medicine. 12th ed. Malden (MA): Wiley & Sons, Ltd; 2014.
    1. Evidence-based management of sickle cell disease: expert panel report, 2014. Bethesda: U.S. Department of Health and Human Services, National Institutes of Health, National Heart Lung and Blood Institute; 2014.

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