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Comment
. 2018 Nov 6;28(5):669-670.
doi: 10.1016/j.cmet.2018.10.011.

Revisiting the Warburg Effect: Some Tumors Hold Their Breath

Sydney M Sanderson  1 , Jason W Locasale  2
Affiliations
Comment

Revisiting the Warburg Effect: Some Tumors Hold Their Breath

Sydney M Sanderson et al. Cell Metab. .

Abstract

Studies have shown that tumors commonly exhibit normal or enhanced respiration in addition to glycolytic metabolism. In this issue, Courtney et al. (2018) report a reduction in mitochondrial function in kidney cancer patients and thus a classic "Warburg Effect" that further illustrates the heterogeneity of human cancer metabolism.

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Figures

Figure 1.
Figure 1.. Human Kidney Tumors Exhibit a Distinct Metabolic Profile from Other Tumor Types
Patient isotope tracing of human brain and lung tumors using 13C-glucose has shown increased glucose uptake and lactate production while maintaining significant glucose oxidation and respiration in the mitochondria. Human ccRCC kidney tumors, however, display markedly different metabolic programming, using glycolysis as a primary energy source with a decrease in mitochondrial respiration, in line with a classic Warburg effect.
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References

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