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Comment
. 2018 Nov 6;28(5):673-675.
doi: 10.1016/j.cmet.2018.10.009.

When Soluble Fibers Meet Hepatocellular Carcinoma: The Dark Side of Fermentation

Suchira Gallage  1 , Elena Kotsiliti  1 , Mathias Heikenwalder  2
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Comment

When Soluble Fibers Meet Hepatocellular Carcinoma: The Dark Side of Fermentation

Suchira Gallage et al. Cell Metab. .
Free article

Abstract

Fermentation of dietary soluble fibers by our gut microbiota generates short-chain fatty acids (SCFAs) and metabolites, upholding health and being a valuable food supplement. Recently, in Cell, Singh et al. (2018) discovered that fermentable, dietary soluble fibers (e.g., inulin) induced cholestasis and hepatocellular carcinoma (HCC) while improving metabolic dysfunction.

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  • Dysregulated Microbial Fermentation of Soluble Fiber Induces Cholestatic Liver Cancer.
    Singh V, Yeoh BS, Chassaing B, Xiao X, Saha P, Aguilera Olvera R, Lapek JD Jr, Zhang L, Wang WB, Hao S, Flythe MD, Gonzalez DJ, Cani PD, Conejo-Garcia JR, Xiong N, Kennett MJ, Joe B, Patterson AD, Gewirtz AT, Vijay-Kumar M. Singh V, et al. Cell. 2018 Oct 18;175(3):679-694.e22. doi: 10.1016/j.cell.2018.09.004. Cell. 2018. PMID: 30340040 Free PMC article.

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