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Case Reports
. 2018 Nov 6;7(4):96.
doi: 10.3390/antibiotics7040096.

First Description of Colistin and Tigecycline-Resistant Acinetobacter baumannii Producing KPC-3 Carbapenemase in Portugal

Cátia Caneiras  1   2 , Filipa Calisto  3   4 , Gabriela Jorge da Silva  5 , Luis Lito  6 , José Melo-Cristino  7   8 , Aida Duarte  9
Affiliations
Case Reports

First Description of Colistin and Tigecycline-Resistant Acinetobacter baumannii Producing KPC-3 Carbapenemase in Portugal

Cátia Caneiras et al. Antibiotics (Basel). .

Abstract

Herein, we describe a case report of carbapenem-resistant Acinetobacter baumannii and Klebsiella pneumoniae isolates that were identified from the same patient at a Tertiary University Hospital Centre in Portugal. Antimicrobial susceptibility and the molecular characterization of resistance and virulence determinants were performed. PCR screening identified the presence of the resistance genes blaKPC-3, blaTEM-1 and blaSHV-1 in both isolates. The KPC-3 K. pneumoniae isolate belonged to the ST-14 high risk clone and accumulated an uncommon resistance and virulence profile additional to a horizontal dissemination capacity. In conclusion, the molecular screening led to the first identification of the A. baumannii KPC-3 producer in Portugal with a full antimicrobial resistance profile including tigecycline and colistin.

Keywords: A. baumannii; Gram-negative bacteria; K. pneumoniae; KPC-3 carbapenemase; antimicrobial resistance; colistin; tigecycline.

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Conflict of interest statement

J.M.-C. received research grants administered through his university and honoraria for serving on the speaker’s bureaus of Pfizer, Gilead and Novartis. The other authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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