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Review
. 2018 Nov 6;10(11):1693.
doi: 10.3390/nu10111693.

Rationale of Probiotic Supplementation during Pregnancy and Neonatal Period

Maria Elisabetta Baldassarre  1 , Valentina Palladino  2 , Anna Amoruso  3 , Serena Pindinelli  4 , Paola Mastromarino  5 , Margherita Fanelli  6 , Antonio Di Mauro  7 , Nicola Laforgia  8
Affiliations
Review

Rationale of Probiotic Supplementation during Pregnancy and Neonatal Period

Maria Elisabetta Baldassarre et al. Nutrients. .

Abstract

Probiotics are living microorganisms that confer a health benefit when administered in adequate amounts. It has been speculated that probiotics supplementation during pregnancy and in the neonatal period might reduce some maternal and neonatal adverse outcomes. In this narrative review, we describe the rationale behind probiotic supplementation and its possible role in preventing preterm delivery, perinatal infections, functional gastrointestinal diseases, and atopic disorders during early life.

Keywords: “Infant, Newborn”[Mesh]; “Pregnancy”[Mesh]; “Probiotics”[Mesh].

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Conflict of interest statement

The authors declare no conflict of interest.

References

    1. Hillman E.T., Yao H.L.T., Nakatsu C.H. Microbial Ecology along the Gastrointestinal Tract. Microbes Environ. 2017;32:300–313. doi: 10.1264/jsme2.ME17017. - DOI - PMC - PubMed
    1. O’Hara A.M., Shanahan F. The gut flora as a forgotten organ. EMBO Rep. 2006;7:688–693. doi: 10.1038/sj.embor.7400731. - DOI - PMC - PubMed
    1. Lay C., Sutren M., Rochet V., Saunier K., Doré J., Rigottier-Gois L. Design and validation of 16S rDNA probes to enumerate members of the Clostridium leptum subgroup in human faecal microbiota. Environ. Microbiol. 2005;7:933–946. doi: 10.1111/j.1462-2920.2005.00763.x. - DOI - PubMed
    1. Gill S.R., Pop M., Deboy R.T., Eckburg P.B., Turnbaugh P.J., Samuel B.S., Gordon J.I., Relman D.A., Fraser-Liggett C.M., Nelson K.E. Metagenomic analysis of the human distal gut microbiome. Science. 2006;312:1355–1359. doi: 10.1126/science.1124234. - DOI - PMC - PubMed
    1. Pickard J.M., Zeng M.Y., Caruso R., Núñez G. Gut microbiota: Role in pathogen colonization, immune responses, and inflammatory disease. Immunol. Rev. 2017;279:70–89. doi: 10.1111/imr.12567. - DOI - PMC - PubMed

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