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. 1987 Aug 4;140(1):109-11.
doi: 10.1016/0014-2999(87)90641-8.

Increase in IP3 precedes alpha-adrenoceptor-induced increase in force of contraction in cardiac muscle

W Schmitz, H Scholz, J Scholz, M Steinfath

Increase in IP3 precedes alpha-adrenoceptor-induced increase in force of contraction in cardiac muscle

W Schmitz et al. Eur J Pharmacol. .

Abstract

In electrically driven left auricles isolated from rat hearts the alpha 1-adrenoceptor agonist phenylephrine increased inositol trisphosphate (IP3) and force of contraction. The increase in IP3 preceded the increase in force of contraction, indicating that the alpha 1-adrenoceptor-mediated increase in IP3 and force of contraction may have been causally related.

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