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. 1987 Sep 14;221(2):332-6.
doi: 10.1016/0014-5793(87)80951-1.

Methylation of the enhancer region of avian sarcoma virus long terminal repeat suppresses transcription

R V Guntaka, S Gowda, H Wagner, D Simon
Free article

Methylation of the enhancer region of avian sarcoma virus long terminal repeat suppresses transcription

R V Guntaka et al. FEBS Lett. .
Free article

Abstract

The effect of methylation of an enhancer on transcription was studied. A 245 bp enhancer-containing a fragment of the LTR of the avian sarcoma virus was methylated in vitro and ligated back into a vector which lacked the upstream enhancer sequence. The transient expression in QT6 cells indicated that methylation of the enhancer-containing sequence severely reduced the extent of transcription.

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