One size does not fit all: Size-based plasma DNA diagnostics

Ellen Heitzer^{1

2

3}, Michael R Speicher^{4

2}

Affiliations

¹ Institute of Human Genetics, Diagnostic and Research Center for Molecular BioMedicine, Medical University of Graz, A-8010 Graz, Austria.
² BioTechMed-Graz, A-8010 Graz, Austria.
³ Christian Doppler Laboratory for Liquid Biopsies for Early Detection of Cancer, A-8010 Graz, Austria.
⁴ Institute of Human Genetics, Diagnostic and Research Center for Molecular BioMedicine, Medical University of Graz, A-8010 Graz, Austria. michael.speicher@medunigraz.at.

Comment

Ellen Heitzer et al. Sci Transl Med. 2018.

. 2018 Nov 7;10(466):eaav3873.

doi: 10.1126/scitranslmed.aav3873.

Ellen Heitzer^{1

2

3}, Michael R Speicher^{4

2}

¹ Institute of Human Genetics, Diagnostic and Research Center for Molecular BioMedicine, Medical University of Graz, A-8010 Graz, Austria.
² BioTechMed-Graz, A-8010 Graz, Austria.
³ Christian Doppler Laboratory for Liquid Biopsies for Early Detection of Cancer, A-8010 Graz, Austria.
⁴ Institute of Human Genetics, Diagnostic and Research Center for Molecular BioMedicine, Medical University of Graz, A-8010 Graz, Austria. michael.speicher@medunigraz.at.

Abstract

Understanding the biological properties of plasma cell-free DNA may expand its applications in oncology (Mouliere et al, this issue).

Enhanced detection of circulating tumor DNA by fragment size analysis.
Mouliere F, Chandrananda D, Piskorz AM, Moore EK, Morris J, Ahlborn LB, Mair R, Goranova T, Marass F, Heider K, Wan JCM, Supernat A, Hudecova I, Gounaris I, Ros S, Jimenez-Linan M, Garcia-Corbacho J, Patel K, Østrup O, Murphy S, Eldridge MD, Gale D, Stewart GD, Burge J, Cooper WN, van der Heijden MS, Massie CE, Watts C, Corrie P, Pacey S, Brindle KM, Baird RD, Mau-Sørensen M, Parkinson CA, Smith CG, Brenton JD, Rosenfeld N. Mouliere F, et al. Sci Transl Med. 2018 Nov 7;10(466):eaat4921. doi: 10.1126/scitranslmed.aat4921. Sci Transl Med. 2018. PMID: 30404863 Free PMC article.