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Comment

. 2018 Nov 20;115(47):11876-11878.

doi: 10.1073/pnas.1817342115. Epub 2018 Nov 7.

Inhibition of tumor growth by agonists of growth hormone-releasing hormone

Hippokratis Kiaris^{1

2}, Ioulia Chatzistamou³

Affiliations

Affiliations

¹ Department of Drug Discovery and Biomedical Sciences, College of Pharmacy, University of South Carolina, Columbia, SC 29208; hk@sc.edu.
² Peromyscus Genetic Stock Center, University of South Carolina, Columbia, SC 29208.
³ Department of Pathology, Microbiology and Immunology, School of Medicine, University of South Carolina, Columbia, SC 29208.

PMID: 30404912
PMCID: PMC6255184
DOI: 10.1073/pnas.1817342115

Comment

Inhibition of tumor growth by agonists of growth hormone-releasing hormone

Hippokratis Kiaris et al. Proc Natl Acad Sci U S A. 2018.

. 2018 Nov 20;115(47):11876-11878.

doi: 10.1073/pnas.1817342115. Epub 2018 Nov 7.

Authors

Hippokratis Kiaris^{1

2}, Ioulia Chatzistamou³

Affiliations

¹ Department of Drug Discovery and Biomedical Sciences, College of Pharmacy, University of South Carolina, Columbia, SC 29208; hk@sc.edu.
² Peromyscus Genetic Stock Center, University of South Carolina, Columbia, SC 29208.
³ Department of Pathology, Microbiology and Immunology, School of Medicine, University of South Carolina, Columbia, SC 29208.

PMID: 30404912
PMCID: PMC6255184
DOI: 10.1073/pnas.1817342115

No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1. — Fig. 1.
Diagrammatic depiction of the endocrine and autocrine loops interrupted by the GHRH agonist MR409 through down-regulation of GHRH receptors.

See this image and copyright information in PMC

Comment on

Agonists of growth hormone-releasing hormone (GHRH) inhibit human experimental cancers in vivo by down-regulating receptors for GHRH.
Schally AV, Wang H, He J, Cai R, Sha W, Popovics P, Perez R, Vidaurre I, Zhang X. Schally AV, et al. Proc Natl Acad Sci U S A. 2018 Nov 20;115(47):12028-12033. doi: 10.1073/pnas.1813375115. Epub 2018 Oct 29. Proc Natl Acad Sci U S A. 2018. PMID: 30373845 Free PMC article.

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References

1. Schally AV, et al. Agonists of growth hormone-releasing hormone (GHRH) inhibit human experimental cancers in vivo by down-regulating receptors for GHRH. Proc Natl Acad Sci USA. 2018;115:12028–12033. - PMC - PubMed
1. Müller E, Pecile A. Growth hormone releasing factor of a guinea-pig hypothalamic extract: Its activity in guinea pig and rat. Proc Soc Exp Biol Med. 1965;119:1191–1194. - PubMed
1. Clark RG, Robinson IC. Up and down the growth hormone cascade. Cytokine Growth Factor Rev. 1996;7:65–80. - PubMed
1. Frohman LA, Szabo M. Ectopic production of growth hormone-releasing factor by carcinoid and pancreatic islet tumors associated with acromegaly. Prog Clin Biol Res. 1981;74:259–271. - PubMed
1. Guillemin R, et al. Growth hormone-releasing factor from a human pancreatic tumor that caused acromegaly. Science. 1982;218:585–587. - PubMed

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