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Review
. 2018 Nov 7;8(11):916.
doi: 10.3390/nano8110916.

Recent Trends in Covalent and Metal Organic Frameworks for Biomedical Applications

Georges Chedid  1 , Ali Yassin  2
Affiliations
Review

Recent Trends in Covalent and Metal Organic Frameworks for Biomedical Applications

Georges Chedid et al. Nanomaterials (Basel). .

Abstract

Materials science has seen a great deal of advancement and development. The discovery of new types of materials sparked the study of their properties followed by applications ranging from separation, catalysis, optoelectronics, sensing, drug delivery and biomedicine, and many other uses in different fields of science. Metal organic frameworks (MOFs) and covalent organic frameworks (COFs) are a relatively new type of materials with high surface areas and permanent porosity that show great promise for such applications. The current study aims at presenting the recent work achieved in COFs and MOFs for biomedical applications, and to examine some challenges and future directions which the field may take. The paper herein surveys their synthesis, and their use as Drug Delivery Systems (DDS), in non-drug delivery therapeutics and for biosensing and diagnostics.

Keywords: biomedicine; covalent organic frameworks (COFs); drug delivery systems; metal organic frameworks (MOFs); nanomaterials.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Growth in research interest of covalent organic frameworks (COFs) and metal organic frameworks (MOFs) for biomedical applications. Based on Google Scholar data [33], retrieved 22 August 2018. Google Scholar search term: ‘“metal organic framework” OR “covalent organic framework” biomed OR drug’.
Figure 2
Figure 2
Concept map of COFs and MOFs as therapeutic and diagnostic agents.
Figure 3
Figure 3
Photodynamic (PDT) and photothermal (PTT) therapy, with COF or MOF agents, against bacteria and cancer cells.
See this image and copyright information in PMC

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