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Comment
. 2019 Feb;16(2):104-105.
doi: 10.1038/s41423-018-0178-9. Epub 2018 Nov 7.

Inscribing the core memories of killers

Sarah J Dulson  1 , Laurie E Harrington  1 , Allan J Zajac  2
Affiliations
Comment

Inscribing the core memories of killers

Sarah J Dulson et al. Cell Mol Immunol. 2019 Feb.
No abstract available

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Conflict of interest statement

The authors have no conflicts of interest to declare.

Figures

Fig. 1
Fig. 1
MCMV-reactive NK cells undergo changes in gene accessibility and expression as they transition from naive to effector and memory states. Lau et al., demonstrate that, upon activation, naive NK cells coordinately change gene accessibility and expression to promote effector phenotype and functions. The epigenetic landscape established by day 14 post-infection is then largely maintained, although gene expression patterns continue to adjust as homeostasis is restored. This results in a population of memory cells that is epigenetically poised to mount anamnestic recall responses
See this image and copyright information in PMC

Comment on

  • Epigenetic control of innate and adaptive immune memory.
    Lau CM, Adams NM, Geary CD, Weizman OE, Rapp M, Pritykin Y, Leslie CS, Sun JC. Lau CM, et al. Nat Immunol. 2018 Sep;19(9):963-972. doi: 10.1038/s41590-018-0176-1. Epub 2018 Aug 6. Nat Immunol. 2018. PMID: 30082830 Free PMC article.

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