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Review
. 1987;3(1):65-73.
doi: 10.1016/0891-5849(87)90040-2.

Free radical modification of low-density lipoprotein: mechanisms and biological consequences

J W Heinecke
Review

Free radical modification of low-density lipoprotein: mechanisms and biological consequences

J W Heinecke. Free Radic Biol Med. 1987.

Abstract

Low-density lipoprotein readily undergoes lipid peroxidation that is accompanied by apoprotein fragmentation. Oxidized forms of low-density lipoprotein show altered biological behavior, including changes in receptor recognition and cytotoxicity to cells in culture. In this review, free radical mechanisms and the biological consequences of low-density lipoprotein modification are discussed.

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