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Review
. 2018 Dec;69(12):984-990.
doi: 10.1007/s00105-018-4299-y.

[Andrological consultation in new systemic oncological therapies with small molecules]

[Article in German]
Till Weidner  1 , Uwe Paasch  2 , Sonja Grunewald  2
Affiliations
Review

[Andrological consultation in new systemic oncological therapies with small molecules]

[Article in German]
Till Weidner et al. Hautarzt. 2018 Dec.

Abstract

Small molecules are rapidly broadening the spectrum of systemic oncologic therapies. Targets of those drugs are-among others-tyrosine and serine/threonine kinases like VEGF-R, EGF-R, Bcr-Abl, c‑kit, JAK, CDK as well as BRAF and MEK. Clinical data of potential risks to male fertility are still very limited and are generally only available for older preparations. In addition, they are often multikinase inhibitors, so that even small molecules with the same (main) target are not completely comparable. For fertility protection, sperm cryopreservation should be offered to men seeking fatherhood before starting targeted therapy.

Keywords: Cryopreservation; Fertility; Gonadotoxicity; Sperm; Targeted therapy.

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