Essential Characteristics of Pharmacogenomics Study Publications

Affiliations

¹ Department of Biomedical Data Sciences, Stanford University, Stanford, California, USA.
² Translational Software, Bellevue, Washington, USA.
³ College of Pharmacy, University of Florida, Gainesville, Florida, USA.
⁴ Genomics England, Queen Mary University of London, London, UK.
⁵ Department of Medicine, The University of Chicago, Chicago, Illinois, USA.
⁶ Pharmaceutical Department, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
⁷ Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
⁸ Sema4, a Mount Sinai Venture, Stamford, Connecticut, USA.
⁹ Department of Genetics, Department of Computer Science, Department of Biomedical Engineering, Stanford University, Stanford, California, USA.
¹⁰ Department of Medicine, Stanford University, Stanford, California, USA.

PMID: 30406943
PMCID: PMC6449845
DOI: 10.1002/cpt.1279

Review

Essential Characteristics of Pharmacogenomics Study Publications

Caroline F Thorn et al. Clin Pharmacol Ther. 2019 Jan.

. 2019 Jan;105(1):86-91.

doi: 10.1002/cpt.1279.

Authors

Affiliations

¹ Department of Biomedical Data Sciences, Stanford University, Stanford, California, USA.
² Translational Software, Bellevue, Washington, USA.
³ College of Pharmacy, University of Florida, Gainesville, Florida, USA.
⁴ Genomics England, Queen Mary University of London, London, UK.
⁵ Department of Medicine, The University of Chicago, Chicago, Illinois, USA.
⁶ Pharmaceutical Department, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
⁷ Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
⁸ Sema4, a Mount Sinai Venture, Stamford, Connecticut, USA.
⁹ Department of Genetics, Department of Computer Science, Department of Biomedical Engineering, Stanford University, Stanford, California, USA.
¹⁰ Department of Medicine, Stanford University, Stanford, California, USA.

PMID: 30406943
PMCID: PMC6449845
DOI: 10.1002/cpt.1279

Abstract

Pharmacogenomics (PGx) can be seen as a model for biomedical studies: it includes all disease areas of interest and spans in vitro studies to clinical trials, while focusing on the relationships between genes and drugs and the resulting phenotypes. This review will examine different characteristics of PGx study publications and provide examples of excellence in framing PGx questions and reporting their resulting data in a way that maximizes the knowledge that can be built on them.

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Conflict of interest statement

Conflict of interest:

RBA is a stockholder in Personalis Inc. and 23andMe, and a paid advisor for Youscript. MJR is a coinventor on a pending patent application for a genomic prescribing system. SAS is a paid employee of Sema4. HH is a paid employee and stockholder in Translational Software.

Figures

**Figure 1.. Checklist for Authors of a PGx study**

See this image and copyright information in PMC

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Essential Characteristics of Pharmacogenomics Study Publications

Affiliations

Essential Characteristics of Pharmacogenomics Study Publications

Authors

Affiliations

Abstract

Conflict of interest statement

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Publication types

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources