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. 2018 Nov 16;20(22):7137-7140.
doi: 10.1021/acs.orglett.8b03083. Epub 2018 Nov 8.

Catalytic Asymmetric Mannich Type Reaction with Tri-/Difluoro- or Trichloroacetaldimine Precursors

Yang'en You  1   2 , Sanzhong Luo  1   2   3
Affiliations

Catalytic Asymmetric Mannich Type Reaction with Tri-/Difluoro- or Trichloroacetaldimine Precursors

Yang'en You et al. Org Lett. .

Abstract

A highly efficient catalytic asymmetric Mannich type reaction of CF3-, CF2H-, or CCl3-acetaldimine precursors by a chiral primary amine is presented. This protocol provides facile access to chiral CF3-, CF2H-, or trichloroethyl amines in excellent yields and high enantioselectivity (up to 99% yield, up to >99% ee).

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